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Maryam Umar Abulfathi, Human Physiology - Ahmadu Bello University, 2021

Diabetes mellitus is a major cause of morbidity and mortality both in developing and developed countries, but about 21% of patients with diabetes develop neuropathy. This study was conducted to evaluate the effect of nicotinamide on serum electrolytes in Alloxan-induced diabetic neuropathic Wistar rats. A total of about thirty six (36) apparently healthy male Wistar rats weighing 100-150g were divided into six experimental groups (n = 6). Group I normal control group (0.1ml of water), group II standard control group (received Glibenclamide 5mg/kg), group III negative control ( received 500mg Nicotinamide) and group IV treatment group (received 1000mg Nicotinamide), Analysis for serum electrolytes after treatment was done by calorimetric method. The result for the serum electrolytes after treatment shows a significant decrease (p < 0.05) in serum sodium level, significant decrease( p < 0.05) In serum potassium level, significant decrease (p <0.05) in chloride level and also significant decrease ( p< 0.05) in serum bicarbonates level when all compare to diabetic (negative) control group. Nicotinamide may be useful in improving the clinical benefit for serum electrolytes changes excluding sodium in diabetes.

Salma Muhammad Kabir, Chemical Engineering - Ahmadu Bello University, 2024

The synthesize of bis(hydroxyethyl) terephthalate (BHET) resins from waste polyethylene terephthalate (PET) bottles presents a promising avenue for recycling and sustainability. This study focuses on the chemical recycling of PET bottles, converting them into valuable BHET resins through a glycolysis process. Waste PET bottles were collected, depolymerized using ethylene glycol, producing bis (2-hydroxyethyl) terephthalate (BHET).The synthesis process was optimized by using six different catalysts (NaOH, Spent FCC, Ammonia, Activated Carbon, Kaolin and DES) to achieve the highest yield and optimal resin properties. Characterization of the synthesized BHET was carried out using Fourier-transform infrared spectroscopy (FTIR) to confirm the functional group which was then compared with commercial bis (2-hydroxyethyl) terephthalate (BHET). The physical properties of the synthesized bis (2-hydroxyethyl) terephthalate (BHET) such as density, viscosity and kinematic viscosity were evaluated. Two out of the six catalysts (NaOH and Spent FCC) yielded 13.3 % and 5 % BHET respectively. This was confirmed by FTIR results comparison with commercial BHET which revealed similar functional group peaks. NaOH was found to be the best catalyst for BHET production, with highest yield conversion 94.4 %. Density, viscosity and kinematic viscosity of resulting BHET from NaOH were 1.27 gcm-3, 10.5 Pa.s and 0.11 m2 /s respectively. The results indicate that the BHET synthesized from waste PET bottles exhibits desirable properties for various industrial applications, such as coatings, adhesives, and composite materials. Additionally, it portrays the environmental impact of the recycling process, highlighting the reduction in carbon footprint and energy consumption compared to traditional disposal methods. This study demonstrates the feasibility of converting waste PET into high-value materials, contributing to waste reduction and resource conservation.

Salma Muhammad Kabir, Chemical Engineering - Ahmadu Bello University, 2024

The synthesize of bis(hydroxyethyl) terephthalate (BHET) resins from waste polyethylene terephthalate (PET) bottles presents a promising avenue for recycling and sustainability. This study focuses on the chemical recycling of PET bottles, converting them into valuable BHET resins through a glycolysis process. Waste PET bottles were collected, depolymerized using ethylene glycol, producing bis (2-hydroxyethyl) terephthalate (BHET).The synthesis process was optimized by using six different catalysts (NaOH, Spent FCC, Ammonia, Activated Carbon, Kaolin and DES) to achieve the highest yield and optimal resin properties. Characterization of the synthesized BHET was carried out using Fourier-transform infrared spectroscopy (FTIR) to confirm the functional group which was then compared with commercial bis (2-hydroxyethyl) terephthalate (BHET). The physical properties of the synthesized bis (2-hydroxyethyl) terephthalate (BHET) such as density, viscosity and kinematic viscosity were evaluated. Two out of the six catalysts (NaOH and Spent FCC) yielded 13.3 % and 5 % BHET respectively. This was confirmed by FTIR results comparison with commercial BHET which revealed similar functional group peaks. NaOH was found to be the best catalyst for BHET production, with highest yield conversion 94.4 %. Density, viscosity and kinematic viscosity of resulting BHET from NaOH were 1.27 gcm-3, 10.5 Pa.s and 0.11 m2 /s respectively. The results indicate that the BHET synthesized from waste PET bottles exhibits desirable properties for various industrial applications, such as coatings, adhesives, and composite materials. Additionally, it portrays the environmental impact of the recycling process, highlighting the reduction in carbon footprint and energy consumption compared to traditional disposal methods. This study demonstrates the feasibility of converting waste PET into high-value materials, contributing to waste reduction and resource conservation.

Maryam Umar Abulfathi, Human Physiology - Ahmadu Bello University, 2021

Diabetes mellitus is a major cause of morbidity and mortality both in developing and developed countries, but about 21% of patients with diabetes develop neuropathy. This study was conducted to evaluate the effect of nicotinamide on serum electrolytes in Alloxan-induced diabetic neuropathic Wistar rats. A total of about thirty six (36) apparently healthy male Wistar rats weighing 100-150g were divided into six experimental groups (n = 6). Group I normal control group (0.1ml of water), group II standard control group (received Glibenclamide 5mg/kg), group III negative control ( received 500mg Nicotinamide) and group IV treatment group (received 1000mg Nicotinamide), Analysis for serum electrolytes after treatment was done by calorimetric method. The result for the serum electrolytes after treatment shows a significant decrease (p < 0.05) in serum sodium level, significant decrease( p < 0.05) In serum potassium level, significant decrease (p <0.05) in chloride level and also significant decrease ( p< 0.05) in serum bicarbonates level when all compare to diabetic (negative) control group. Nicotinamide may be useful in improving the clinical benefit for serum electrolytes changes excluding sodium in diabetes.

Olubodun David Toluwabori, Chemistry - Obafemi Awolowo University, 2024

This study focused on investigating dapsone and its schiff bases as potential antibiotic agents. Oseltamivir is a well-established antibiotic drug used to treat leprosy. However, research on its schiff bases derivatives is limited. This study aimed to characterize these derivatives in terms of their properties and potential as antibiotic agents. A series of ten schiff bases of dapsone were computationally designed and subjected to in-depth analysis. These derivatives were evaluated across multiple parameters including physicochemical properties, pharmacokinetic behavior, toxicological profile, and potential interactions with a biological target. To achieve this, computational methodologies were employed. Computational studies were conducted to evaluate the potential of the schiff bases of dapsone as drug candidates. The compounds' electronic properties and reactivity were assessed using the Spartan'14 software package. Density Functional Theory (DFT) calculations at the B3LYP/6-31G* level were employed for further refinement. Drug-likeness was evaluated based on Lipinski's Rule of Five, while ADMET properties and toxicity profiles were predicted using computational tools. Molecular docking simulations against reductase (PDB ID: 1zid) were performed to assess the compounds' potential as antibiotic agents. Several derivatives exhibited promising drug-like properties, acceptable toxicity profiles, and favorable binding affinities to the target protein, suggesting their potential as lead compounds for further development. Physicochemical properties including partition coefficient (logP), total energy, dipole moment, and polarizability were computed for the compounds. Pharmacokinetic properties, encompassing absorption (HIA), distribution (including skin permeability and plasma protein binding), metabolism, excretion, and toxicity, were predicted using the Pre-ADMET online platform. Additionally, toxicity endpoints such as LC50 were estimated using the T.E.S.T 4.2 software. This comprehensive approach enabled the identification of key structural features influencing the compounds' behavior and provided insights into their suitability as drug candidates.

Luqman Abdulmumin, Community Medicine - Ahmadu Bello University, 2025

Female genital mutilation and cutting (FGM) describes procedures involving partial or total removal of the external female genitalia or other injury to the female genital organs for non-medical reasons. The prevalence of FGM in Nigeria, according to the Nigerian Demographic and Health Survey, was 20% as of 2018. This practice carries a lot of health and economic consequences. This study aimed to assess the knowledge, attitude, and practice of FGM among residents of Maraban Guga community. A community-based cross-sectional study was conducted. Multistage sampling technique was employed to select the wards. Selection of houses was done using systemic random sampling. Data were collected using a semi-structured interviewer-administered questionnaire and analysed using SPSS. A total of 106 women of reproductive age participated in the study, with a 100% response rate and a mean age of 29 years. Findings reveal that 57.5% of the participants have undergone FGM, 45.3% have practiced it on their daughters, 71.7% have poor knowledge, and 66% have a positive attitude towards FGM; 51.9% of the respondents intend to continue the practice. A significant association was noted between the respondent’s level of education, knowledge, and practice of FGM, as well as between respondents’ FGM status and intention to practice it on future daughters. The study revealed that the prevalence of FGM is high in Maraban-Guga, with a large proportion of participants still willing to subject their future daughters to it. Targeted interventions aimed at addressing wrong beliefs and attitudes regarding the sexual, health, or socio-cultural benefits of FGM and improved public legislation against FGM are recommended.

Maryam Daud, Human Anatomy - Bayero University, Kano, 2025

This study investigates the relationship between occipito frontal circumference (OFC) and ponderal index (PI) with maternal age and parity among neonates. The study was conducted in three hospitals in Kano which are; murtala Muhammad specialist hospital, Muhammad Abdullah Wase teaching hospital and hasiya bayero pediatrics. The aim was to determine how maternal factors such as age and number of children (i.e parity) influence neonatal Anthropometric indices in particular OFC and PI. A total of 150 neonates and their mothers were used in this cross sectional study. Descriptive statistics was used to determine the mean values of OFC and PI which were found to be 32.690cm and 2.643g/cm³ respectively. Pearson's coefficient of correlation was used to determine the relationship between maternal age, OFC and PI. The r-value between maternal age and OFC was found to be 0.399 with p<0.01 which shows a moderate positive correlation which is statistically significant while the r-value between maternal age and PI was found to be 0.273 with p<0.05 which shows a weak yet positive correlation which is statistically significant. Furthermore, student t-test was used to determine the relationship between OFC and PI across different parity groups. It was observed that neonates born to mothers with higher parity had a significantly larger mean OFC (33.58cm) compared to those with low parity(32.18cm) with p<0.05 while the mean PI did not differ significantly between the two groups (p> 0.05).